The Frenchman did not travel with the rest of the team on Saturday afternoon.
Fassou Antoine, 79, passed on after a long illness.
Manager Jose Mourinho, will also be without another midfielder, Marouane Fellaini, who missed the match at White Hart Lane as he serves the final game of his three-match ban.
Scott McTominay and Axel Tuanzebe were joined in the travelling party by Demetri Mitchell, Matty Willock and Matt Olosunde.
Mourinho is likely to pick a young midfielder, with the Portuguese having prioritized the Europa League where they face Ajax in the final later this month.